King County’s fish tissue monitoring does not include data on pharmaceuticals and personal care products (PPCPs), chemicals in common household cleaners or antibacterials in soaps and other consumer products. The absence of such information is a data gap. Information to describe the presence/absence of such chemicals in the fish tissues routinely monitored through existing programs is needed to determine whether these chemical of emerging concern should be further studied in tissue. The goal of the study is to describe basic information on presence/absence and concentrations of 142 PPCPs, triclosan, and octylphenol, nonylphenol and nonylphenol ethoxylates in whole fish. The study objective is the capture of up to 18 whole fish samples for analysis from Lake Union and Elliott Bay in May and/or June of 2021, when regular King County monitoring sample collections will be conducted. Therefore, samples will represent a 2021 snapshot of the subject analytes in fish tissue at these select locations in King County. Analysis will include qualitative comparisons to results of other studies or to comparable data developed in the future; descriptive results on presence/absence of each analyte in each location and species; and evaluation of within-species individual level variation in each detected analyte. This QAPP presents the plan for obtaining the data.